Only replace the Main Jet with one size larger after properly tuning your slow/idle jet settings. Main Jets are sized incrementally by 5, so if your stock jet was a #175 the next size larger will be #180. you should only increase the jet sizing one size at a time. Avoid installing jets that are too rich as this will create a sluggish feeling at full throttle as well as contribute to plug fouling.
Many Twin Cam models (except California) are already appropriately jetted with a main jet that will allow for a good starting point for tuning. As mentioned, proper mixture adjustment is key to proper jetting and should be performed first.
Reinstall the bowl making sure to align the accelerator pump shaft and rubber boot. Install the carburetor back onto the bike and perform the tuning procedure as described under Carburetor Tuning.
As you can see, Harley carburetor jetting is a fairly simple procedure that under most conditions will yield greater performance when requiring a richer fuel mixture.
Enjoy the Ride!